Abstract
Rhizopycnis acids A (1) and B (2), two new anisic acid derivatives, were obtained from the ethyl acetate extract of the fermentation cultures of Rhizopycnis vagum, an endophytic fungus isolated from the healthy tissues of Nicotiana tabacum. The structures of the two compounds were determined through a series of 1D and 2D NMR and HRMS spectral analyses. Both compounds were the first anisic acid derivatives containing methylbutanoic/methylbutenoic acid group found in fungi. 1 and 2 displayed antibacterial activity against six tested bacteria with IC50 values in the range 16.1~81.3 μg/mL.
Highlights
(2), two two new new anisic anisic acid acid derivatives, derivatives, were were obtained obtained from from
The anisic acids with their structures containing methylbutanoic or methylbutenoic acid group (1 and 2) represent a new class of natural products found in fungi
Its gene sequence was submitted to GenBank database to obtain the accession number KM095527, and the pure cultures were deposited at the Department of Plant Pathology, China Agricultural University, Beijing, China
Summary
(2), two two new new anisic anisic acid acid derivatives, derivatives, were were obtained obtained from from. Rhizopycnis vagum, vagum, an endophytic endophytic fungus fungus isolated from from the the healthy healthy tissues tissues of of Nicotiana. The structures of of the the two two compounds compounds were were isolated. In our ongoing for new metabolites bioactive metabolites from this fungus, two new acid derivatives search forsearch new bioactive from this fungus, two new anisic acid anisic derivatives containing containing methylbutanoic or methylbutenoic acid group They were screened for screened for activities. We reported the reported isolation, the structural elucidation, antibacterial antibacterial activity of these two compounds. Molecules 2018, 23, 591; doi:10.3390/molecules23030591 www.mdpi.com/journal/molecules www.mdpi.com/journal/molecules
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