Abstract
Two new alkaloids, hypserpanines A and B ( 1, 11), together with eleven known compounds, phenolbetain ( 2), acutumine ( 3), acutumidine ( 4), dechloroacutumine ( 5), dauricumine ( 6), dauricumidine ( 7), pronuciferine ( 8), glaziovine ( 9), S-reticuline ( 10), magnoflorine ( 12) and laurifoline( 13), were isolated from Hypserpa nitida Miers. (Menispermaceae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine ( 7), exhibited an IC 50 value of 0.450 mM (SI = 4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line.
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