Abstract
Abstract Two novel mixed-ligand coordination polymers, {[Co(tdc)(btrp)]·0.67DMF} n (1) and {[Zn2(bimb)2(tdc)2]·2H2O} n (2) involving 2,5-thiophenedicarboxylate (H2tdc), and bitopic flexible N-donor ligands, 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) and 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene (bimb), have been synthesized by the hydrothermal method and characterized via IR, elemental analysis, thermal analysis, and powder X-ray diffraction. The biological functional studies were performed; the treatment activity of the compounds on periodontitis and the specific mechanism was explored. First, the real-time RT-PCR was carried out to determine the inflammatory genes nf-κb and p53 relative expression in periodontal mucosal cells after treating with compounds 1 and 2. Then, the level of the inflammatory cytokine in the gingival crevicular fluid after treating with compounds was also determined by the ELISA detection kit.
Highlights
Periodontitis is one of the most common oral diseases worldwide
The reasonable selection of the functional group, rigidity, and length of co-ligand or organic ligand is very significant for structure-controlled coordination polymers (CPs) assembly, and many important works have been completed via utilizing this strategy [11,12,13]
In addition to carboxylic acid linkers, flexible bisimidazole and its derivatives have multiconformation and strong coordination ability, which can be utilized as the auxiliary ligands in order to construct fascinating metal CPs [17]
Summary
Periodontitis is one of the most common oral diseases worldwide. Studies have shown that the invaded pathogens could adhere to the gums and periodontal tissues, multiply, grow, and the metabolic substance produced by the invaded pathogens can activate the immune system, causing edema and bleeding of soft. The structural diversity of these crystal materials is decided by many factors such as counterions, templates, metal coordination ratio, metal ions, the value of pH, and the coordination of organic ligands [8,9,10] In these specific strategies, the reasonable selection of the functional group, rigidity, and length of co-ligand or organic ligand is very significant for structure-controlled CPs assembly, and many important works have been completed via utilizing this strategy [11,12,13]. Involving 2,5-thiophenedicarboxylate (H2tdc), and bitopic flexible N-donor ligands, 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) and 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene (bimb), have been synthesized by hydrothermal method and characterized via IR, elemental analysis, thermal analysis, and powder X-ray diffraction (Scheme 1). 2.2 Preparation and characterization for {[Co(tdc)(btrp)]·0.67DMF}n (1) and {[Zn2(bimb)2(tdc)2]·2H2O}n (2)
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