Two mixed-ligand Cu(II)-based coordination polymers: crystal structures and treatment activity on child acute pancreatitis with peritonitis by inhibiting bacterial survival

Abstract

Two mixed-ligand coordination polymers with the chemical formulae {[Cu3(Hdpc)2(tib)2·(H2O)2]·2H2O)}n (1, H3dpc = 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid, tib = 1,3,5-tris(1-imidazolyl)benzene)) and [Cu(trans-chda)2(bimb)2·2H2O]n (2, H2chda = 1,4-cyclohexane(dicarboxylic)acid, bimb = 1,4-bis((1H-1,2,4-triazol-1-yl)methyl)benzene) are successfully prepared by the reaction of Cu(NO3)2·3H2O with different O-donor carboxylic acid and N-donor co-ligands under the solvothermal conditions. Furthermore, the treatment effect of the two compounds on the acute pancreatitis is evaluated in the biological experiment. Firstly, RT-PCR is performed to measure the relative expression level of the key genes of E. coli. Moreover, the inflammatory levels of the patients are evaluated by the ELISA detection of inflammatory cytokines, IL-1β, and TNF-α.