Two metal-coordination polymers: Photocatalytic hydrogen production and clinical nursing value on gastric cancer combined with hyperthermic intraperitoneal chemotherapy by inducing induce oxidative stress response.

Abstract

Two new coordination polymers (CPs) of {[Dy2(abtc)1.5(H2O)3(DMA)]·H2O·DMA}n (1; DMA=N,N-dimethylacetamide) and [NH2(CH3)2][Ni1.5(abtc)]·H2O (2) were synthesized through utilizing 3,3',5,5'-azobenzenetetracarboxylic acid (H4abtc) as an organic connector with the solvothermal reaction conditions. The HOMO-LUMO gap for ultra-stable complex 1 is 2.16eV through the detection of the ultraviolet-visible spectrum with an absorption edge of 570nm. The complex 1 reveals high catalytic effect for the ultraviolet-visible photocatalytic production of hydrogen, which is due to its light collection of the ligand with dye-like and porous architecture. Furthermore, the promotion effect of compounds 1 and 2 against the gastric cancer treatment was assessed when combined with intraperitoneal hyperthermia. Firstly, the inhibition of compounds 1 and 2 against the invasion and migration of cancer cells was evaluated with transwell assay. Moreover, the genes relative expression levels related with the reactive oxygen species (ROS) production in the cancer cells were also measured with real time reverse transcription-polymerase chain reaction (RT-PCR).