Abstract

Limonoid compounds are found in the Meliaceae family, especially in the genus Chisocheton. This genus belongs to medicinal plants with limonoid content that contains various biological activities such as anticancer, antimalarial, anti-inflammatory, insecticide, antiviral, neuroprotective and antimicrobial properties. One of them which was not much reported is Chisocheton lasiocarpus. This study aims to get the new limonoid compound of C. lasiocarpus seeds. C. lasiocarpus seeds were macerated using methanol and were partitioned using n-hexane, ethyl acetate and butanol. The presence of limonoid was guided using the Ehrlich reagent. Extract of n-hexane was collected and purified by the chromatographic method until two pure isolates was obtained as nimonol (1) and 6α-acetoxy-14β,15β-epoxyazadirone (2). The chemical structure of isolates were identified by spectroscopic data including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY) and by comparison to those related spectra reported previously.

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