Abstract
Two unique isonardosinane-type sesquiterpenoids, isonardosinonetriols A and B, together with six known sesquiterpenoids teucladiol, bullatantriol, (−)-globulol, (+)-maaliol, nardoguaianone J, and (+)-orobanchyl acetate, were isolated from the roots and rhizomes of Nardostachys jatamansi DC. (Caprifoliaceae). Their structures were elucidated by analysis of extensive spectroscopic data and the relative configurations were established by NOESY and circular dichroism (CD) experiments. Further, the results of SERT activity evaluations indicated that isonardosinonetriols A and B, (+)-maaliol and nardoguaianone J significantly enhanced SERT activity.
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