Abstract
A procedure is given for the preparation of the hydrated potassium salt of 6-N-tritylaminopenicillanic acid (1). Conversion of 1 to the acid chloride followed by treatment with triethylamine produced the anhydro derivative 2. Reaction of 2 with p-toluenesulfonic acid monohydrate gave the p-toluenesulfonic acid salt 3 of anhydro 6-aminopenicillanic acid. The free base 4 was generated with sodium bicarbonate; acylation with phenylacetic acid by the carbodiimide method afforded anhydropenicillin G.
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