Two Furanosesterterpenoids from the Sponge Luffariella variabilis.

Peni Ahmadi,Masahiro Higashi,Nicole J De Voogd,Junichi Tanaka

doi:10.3390/md15080249

Peni Ahmadi, Masahiro Higashi + Show 2 more

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https://doi.org/10.3390/md15080249

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Abstract

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.

Highlights

Among sessile marine macroorganisms, sponges have remained the richest sources of new bioactive molecules [1]
We report structures of two new sesterterpenoids isolated from a specimen of L. variabilis collected at a deeper coral reef
As a part of collaborative efforts to search for antiviral molecules [13], we constructed a small library of Okinawan marine invertebrates

Summary

Introduction

Sponges have remained the richest sources of new bioactive molecules [1]. Those belonging to the family Thorectidae are known as sources of sesterterpenoids and other molecules [2,3,4,5,6,7,8,9,10,11,12]. Additional members of sesterterpenoids with a similar molecular scaffold have been reported from different collections of sponges of the same genus [6,7,8,9,10,11,12]. We report structures of two new sesterterpenoids isolated from a specimen of L. variabilis collected at a deeper coral reef

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