Abstract
An experiment was performed to evaluate what intragastric factors led to hunger satiety. Is it the presence of a certain amount of nutrient in the stomach that produces satiety or is it simply sheer volume? As rats drank nutrient, saline was counterinjected into the stomach in proportion. It was found that with heavy drinkers, intragastric volume alone regulated intake. With light drinkers, another factor was present as volume played a much smaller role. A second experiment in which nutrient was siphoned off as the rats drank suggests that amount of intragastric nutrient as opposed to volume alone may also play a part in meal size regulation.
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