Abstract
Deterministic lateral displacement (DLD) technology has great potential for the separation, enrichment, and sorting of red blood cells (RBCs). This paper presents a numerical simulation of the motion of RBCs using DLD devices with different pillar shapes and gap configurations. We studied the effect of the pillar shape, row shift, and pillar diameter on the performance of RBC separation. The numerical results show that the RBCs enter “displacement mode” under conditions of low row-shift (∆λ < 1.4 µm) and “zigzag mode” with large row shift (∆λ > 1.5 µm). RBCs can pass the pillar array when the size of the pillar (d > 6 µm) is larger than the cell size. We show that these conclusions can be helpful for the design of a reliable DLD microfluidic device for the separation of RBCs.
Highlights
Human blood consists of plasma and mainly red and white blood cells and platelets [1]
ReTsoulstismapnldifyDtihsecussimsiounlation, we consider the red blood cells (RBCs) to be microscopically deformed microspheres by igTnoosriimngpltihfyeitrhdeesfiomrmulaabtiiolinty, wine ocordnesridteor sthtuedRyBtChse tdoebfleecmtiiocnroescffoepcitcoafllyDdLeDfodrmeveicdems oicnrodsipffheerreenst bsyizeigdnmoriicnrgostphheeirredse. fTohrmreaebkiliintdysinofomrdiecrrotsopshteurdesy wthiethddeiflffeecrteionnt deiffaemctetoefrsDwLDeredeuvseicdesfoornnduimffeerreicnatl ssiizmedulmatiicornoss;pthheeretsr.aTjehctroereieksinodfs tohfemmicircorsopshpehreerseswiftlhowdiinffgerethnrtoduigamh ettheersDwLeDre musiecdrofcohrannunmelewricearle sainmaulylazteiodn. s; the trajectories of the microspheres flowing through the Deterministic lateral displacement (DLD) microchannel were analyzed
We studied the factors affecting the separation of microspheres in the DLD device, the row shifts fraction ε, and the diameter of the microspheres D
Summary
Human blood consists of plasma and mainly red and white blood cells and platelets [1]. RBCs are the most critical component, and have a direct impact on hemodynamics and hemorheology. RBCs are highly deformable due to their biconcave, seedless, and highly flexible membrane [2]. Researchers has recognized the deformability of RBCs as an inherent indicator of diseases such as diabetes and malaria. The separation of deformable RBCs through Lab-on-a-chip techniques, which is based on the formers’ mechanical properties, is becoming an essential process for medical research and clinical disease diagnosis [3,4,5]. Further understanding of the dynamic behavior of the RBCs in a microchannel, and exploring new methods by which to efficiently separate RBCs from plasma, are urgent to the development of biomedical engineering
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