Abstract
To improve the reproducibility of photocoagulation, the ability to quantitatively monitor the thermal change of laser-irradiated retinal tissue is required. Recently, optical coherence tomography has enabled non-invasive and non-contact monitoring of the tissue structural changes during laser irradiation. To further improve the capability of this technique, a method is proposed to measure tissue displacement by simultaneously using Doppler phase shifts and correlation coefficients. The theoretical approach for this method is described, and its performance is experimentally confirmed and evaluated. Finally, lateral and axial displacements in the laser-irradiated retinal tissues of an enucleated porcine eye are observed. The proposed method is found to be useful for further understanding the direct thermal response of laser-irradiated retinal tissue.
Highlights
Photocoagulation is an effective laser treatment that has been successfully used for eye diseases such as diabetic retinopathy [1, 2], retinal vein occlusion, [3, 4], and retinal detachment
We evaluated the performance of the correlation coefficient-based displacement measurement
We have demonstrated a spatially-resolved, rigid-body, in-plane displacement measurement method using the correlation coefficient and the Doppler phase shift
Summary
Photocoagulation is an effective laser treatment that has been successfully used for eye diseases such as diabetic retinopathy [1, 2], retinal vein occlusion, [3, 4], and retinal detachment. There are iatrogenic complications owing to this treatment, with the most significant drawback being excessive laser damage due to overtreatment. To prevent such damage, it is required that laser irradiation parameters be set at a level that is less than the damage threshold with high reproducibility. It is required that laser irradiation parameters be set at a level that is less than the damage threshold with high reproducibility This requirement is challenging because the laser treatment has poor reproducibility. Because there are many uncertainties concerning tissue alteration during laser treatment, a quantitative monitoring technique is required
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