Abstract
Brain is inhomogeneous due to its composition of different tissue types (gray and white matter), anatomical structures (e.g. thalamus and cerebellum), and cavities in the brain (ventricles). These inhomogeneities lead to spatial variations in the ultrasonic properties of the organ. The goal of this study is to characterize the spatial variation of the speed of ultrasound and frequency slope of attenuation in fixed sheep brain. 1-cm-thick slices of tissue from the coronal, sagittal and transverse cardinal planes were prepared from 12 brains. Ultrasonic measurements were performed using broadband transducers with center frequencies of 3.5, 5.0, 7.5 and 10 MHz. By mechanically scanning the transducers over the specimens, two-dimensional maps of the speed of sound (SOS) and frequency slope of attenuation (FSA) were produced. Measured values for the spatial mean and standard deviation of FSA ranged between 0.59 and 0.81 dB/cm·MHz and 0.29–0.60 dB/cm·MHz, respectively, depending on the specimen and transducer frequency. Measured values for the spatial mean and standard deviation of SOS ranged from 1532–1541 m/s and 10–14 m/s, respectively. Detailed, two-dimensional maps of FSA and SOS were produced, representing the first such characterization of the spatial variation of the ultrasonic properties of normal mammalian brain.
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