Abstract
A short-term test for human cellular response to toxic environmental chemicals using peripheral blood leukocytes and high-resolution two-dimensional electrophoresis is demonstrated to be feasible by using extracts of organic compounds from municipal incinerator fly ash and from particulates of diesel exhaust and air-borne particulates. The effect of the chemicals on the normal synthesis of about 2000 proteins by the leukocytes is observed. Three types of effects by adding increasing amounts of chemicals are found: proteins whose synthesis is blocked easily; those that are quite resistant; and the appearance of new proteins. The type of effect which predominates appears to be related to composition of the organic extract. It is anticipated that this test can directly measure the toxic, genotoxic, and mutagenic behavior of individual chemicals or mixtures on human cells. 8 figures, 1 table.
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