Two different concentrations of Opti-Plus® compared for daily protein cleaning of a disposable contact lens

Abstract

The aim of this study was to compare the relative safety, efficacy, comfort, and convenience of the daily use of a pancreatin-based, liquid enzyme daily protein remover (DPR) at two different concentrations for protein cleaning of Group IV disposable contact lenses. We enrolled 73 subjects (146 eyes) into a 3-month, randomized, investigator-masked clinical study comparing a test regimen of DPR (Opti-Plus® or Supra-Clens®) containing four drops per 10 mL of multifunctional solution (Opti-Free®) to a control regimen containing only two drops per 10 mL of multifunctional solution. The liquid enzyme regimens provided safe and effective protein cleaning of the Group IV lenses with no additional cleaning benefit observed at the higher concentration. Three convenience parameters (steps required, time required, and dexterity required) had mean improvements for both regimens at Day 90 compared to baseline (Day 0). Thus, subjects perceived the DPR regimen as more convenient than their pre-study regimen, which required weekly use of an enzymatic cleaning tablet. Comfort remained consistent with baseline levels throughout the study regardless of concentration of DPR for 72 of 73 subjects. This study provided evidence that the daily use of a low concentration pancreatin enzymatic solution admixed with multifunctional solution is well tolerated and provides a more convenient method of achieving simultaneous disinfection and protein cleaning during contact lens storage than enzyme tablets.