Abstract
A series of compounds ( 1– 4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg 2+ in a 100% aqueous solution with high sensitivity ( K d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg 2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg 2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg 2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg 2+ complex.
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