Abstract
The genus Astragalus is the largest one in the Fabaceae family. Several species are used in traditional medicine for the treatment of diabetes mellitus, nephritis, and leukemia [1]. Chemical studies on Astragalus saponins have provided oleanane-type and cycloartane-type triterpenoid glycosides that exhibited cytotoxic, immunostimulatory, hepatoprotective, or antiviral activities [2]. In the field of our ongoing search for triterpene saponins from Astragalus genus [3,4], a phytochemical investigation of A. glycyphyllos, an endemic plant in France, was carried out. The n-butanol fraction from the methanol extract of the roots was submitted to several solid/liquid preparative chromatographic methods such as flash, VLC, MPLC over silica gel and reversed phase RP18. Two known cycloartane-type glycosides called Askenoside C and Askenoside F previously isolated from A. taschendicus [5,6] were now isolated from A. glycyphyllos. Although saponins have already been found in A. glycyphyllos [7,8], we isolated for the first time triterpenoid glycosides from the cycloartane-type from this plant.
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