Abstract
Two cycles of Atosiban in preventing preterm birth in twin pregnancies
Highlights
Twin gestation contributes significantly to perinatal morbidity and mortality related to high occurrence of preterm birth
After 48 hours from the end of the first cycle of Atosiban, 98 women didn’t show uterine contractions and/or cervical length modifications; 34% of them delivered before 34 weeks
The overall rate of delivery before 34 weeks in the studies groups was of 16%. In this retrospective study repeated Atosiban administration resulted effective in prolonging twin pregnancies
Summary
Twin gestation contributes significantly to perinatal morbidity and mortality related to high occurrence of preterm birth. The number of assisted-reproduction twins have been increasing, doubling the twining rates in Western countries [1]. Twin gestations imposed financial and psychological burdens on the family and society [2]. In Campania, a Southern region of Italy, the birth rate from assisted reproduction increased from 6% in 2007 to 16,5% in 2012. The increased risk of maternal and fetal morbidity associated with twin compared with singleton pregnancies is nowadays the strongest argument for single embriotransfer in the debate of assisted reproduction. At least 60% of all twins are born before the 37th week of gestation. In the last seven years twin gestation in our department increased from 3.5% to 7.7% in 2013. In several double blind trials Atosiban has demonstrated a tocolytic effectiveness similar to beta agonists, with the advantages of no side effects due to its specific effect on uterine tissue [3,4]
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