Two Cu(II)-based coordination polymers: inhibitory activity on the ovarian cancer cell invasion and migration by regulating the miRNA16 expression

Abstract

In the present study, by employment of a bifunctional ligand 5-(triazol-1-yl)nicotinic acid (HL) containing both triazole and carboxylate groups, two new transition metal coordination polymers {[Cu(L)(H2O)0.5(DMF)0.5(NO3)0.5]·(Cl)0.5·DMF·2H2O} n (1) and {[Cu2(L)4(H2O)]·2DMA·2H2O} n (2) have been successfully prepared by reaction of Cu(NO3)2·3H2O with the HL ligand in different solvent systems. Furthermore, the treatment ability of compounds 1 and 2 on the ovarian cancer cell invasion and migration was evaluated and the related mechanism was discussed at the same time. First of all, the trans-well assay was performed and the influence on the ovarian cancer cell invasion and migration was assessed. Then, the real time RT-PCR was conducted to measure the expression levels of the miRNA16 in the cancer cells after treatment.