Two Cu(ii)-based coordination polymers: Crystal structures and treatment activity on periodontitis

Yipu Xu,Xiangzhe Zhao,Xiangchun Li,Zhifang Wu

doi:10.1515/chem-2021-0119

Yipu Xu, Xiangzhe Zhao + Show 2 more

Open Access

https://doi.org/10.1515/chem-2021-0119

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Abstract

Abstract Two new Cu(ii)-based coordination polymers (CPs) with the chemical formulae of [CuL(bimmb)0.5] n (1, bimmb is 4-bis(imidazole-1-ylmethyl)benzene) and [CuL(bbibp)] n (2, bbibp is 4,4'-bis(benzoimidazo-1-yl)biphenyl) have been successfully prepared by the reaction of 3,3'-azodibenzoic acid (H2L) ligand and metal salt Cu(NO3)2·3H2O in the presence of different nitrogen-donor coligands. In the bioactive evaluation experiments, the treatment activity of the prepared CPs against periodontitis was examined. Enzyme-linked immunosorbent assay detection was used to test interleukin-18 (IL-18) and IL-6 contents released into the gingival crevicular fluid after the treatment of above CPs, and the real-time reverse transcription polymerase chain reaction was subsequently performed to measure the relative expression level of HmuY gene in the Porphyromonas gingivalis.

Highlights

Periodontitis is a chronic infectious disease caused by the host’s immune response induced by pathogenic microorganisms in the oral cavity [1]
The as-generated two CPS are characterized through the IR spectra, elemental analysis (EA), the diffraction of singlecrystal X-ray, thermogravimetric analysis (TGA), and powder X-ray diffraction (PXRD)
IR (KBr disk, cm−1): 656 (w), Enzyme-linked immunosorbent assay (ELISA) test was used for detecting the IL-18 content together with IL-6 content released into the gingival crevicular fluid after treating via compounds

Summary

Introduction

Periodontitis is a chronic infectious disease caused by the host’s immune response induced by pathogenic microorganisms in the oral cavity [1]. # Authors have contributed to this study. [CuL(bbibp)]n (2, bbibp is 4,4'-bis(benzoimidazo-1-yl)biphenyl) and [CuL(bimmb)0.5]n (1, bimmb is 4-bis(imidazole-1-ylmethyl) benzene), have been generated with the reaction between 3,3'azodibenzoic acid (H2L) ligand and metal salt Cu(NO3)2·3H2O in the presence of various nitrogen-donor coligands. The as-generated two CPS are characterized through the IR spectra, elemental analysis (EA), the diffraction of singlecrystal X-ray, thermogravimetric analysis (TGA), and PXRD. The treatment effect against periodontitis was assessed, and the mechanism was explored

Chemicals and measurements

Crystal structures

Conclusion