Two corneal donor tissues for 5 different recipients

Abstract

Objective To evaluate the feasibility and to discuss the methods of using two donor corneal tissue in multiple patients. Methods One donor corneal tissue was divided into 3 parts: The anterior lamellar part were transplanted into a patient with corneo-conjunctival malignant melanoma and a patient with corneal perforation of Mooren's ulcer using lamellar keratoplasty technique; The posterior part was transplanted into a patient with bullous keratopathy using deep lamellar endothelial keratoplasty technique. The other donor corneal tissue was divided into 2 parts: The anterior part was transplanted into a patient with severe symblepharon after ocular surface thermal burn using full bed lamellar keratoplasty. The posterior part was transplanted into another patient with bullous keratopathy using deep lamellar endothelial keratoplasty technique. Results All surgical procedures were performed successfully. At 1 month after surgery, the grafts were transparent in both of the eyes with bullous keratopathy. Epithelial bulla disappeared and cornea edema relieved in both cornea. The best corrected visual acuity of the patient with corneo-conjunctival malignant melanoma improved from 0.3 preoperatively to 0.6 postoperatively. The graft remained transparent and no pigment remained in the conjunctiva and graft bed of recipient. The patient with corneal perforation of Mooren's ulcer were cured after amniotic membrane transplantation combined with partial lamellar keratoplasty. At 1 month, the best corrected visual acuity was improved from 0.1 preoperetively to 0.3 postoperatively in the patient with severe symblepharon. The graft remained transparent and the symblepharon was relieved. Conclusion To make good use of donor cornea, we can use one donor cornea to treat multiple patients. Key words: Corneal transplantation; Corneal disease; Prognosis