Abstract
A review of the literature presents data on two-component bacterial regulatory systems that may be possible targets in the search of new antibacterial drugs because of their universality and the role in regulation of pathogenicity. We discuss (a) the structural-functional organization of two-component systems taking as example OmpR family (EnvZ/OmpR and PhoQ, PhoP) regulating a number of processes in bacteria faciliting adaptation to stress from changes in the environment and human host, providing virulence and formation of biofilms, these being a cause of many human chronic infections, and (b) the genes and functions regulated by two-component systems by EnvZ/OmpR system, OmpR protein in particular, and PhoQ/PhoP. The review speculates on possibilities of searching for inhibitors of the proteins of two-component systems and their possible role in virulence attenuation of pathogenic bacteria.
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