Abstract
ABSTRACT We discuss the combination of a CARS-imaging system with mi crofluidics. Such system is a versatile tool to quantify the relative contributions of resonant and non-resonant scattering at the CARS frequency. We will show that the two-channel microfluidic chip employed in combination with deuter ated isotopomers as an intern al standard allows for fast and quantitative detection of organic molecules by CARS microscopy. The experimental design enables the simultaneous measurement of both the chemically relevant Raman-resonant signal and the non-Raman-resonant background. Keywords: Coherent anti-Stokes Raman microscopy, Raman spectroscopy, microfluidics, nonresonant background, analytical methods, isotopomers 1. INTRODUCTION Over the last decade Raman microspectroscopy 1-17 matured into a powerful widespread technique for biomedical diagnostics. This success is based on th e capability of the technique to record chemical images based on intrinsically label-free vibrational
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