Abstract
Two cases with stage II tongue cancer who exhibited different responses to intra- and peri-tumoral administration of rIL-2 alone are presented. Special consideration is given to the relationship between tumor responses to rIL-2 and clinicopathological and immunohistopathological findings. The patient who responded completely to treatment showed an exophytic tumor growth pattern, low-grade cancer invasion, and predominant infiltration of CD8+ lymphocytes over CD4+ lymphocytes in cancer cell nests. The non-responder showed endophytic tumor growth, high-grade cancer invasion, and uniform distribution of both CD4+ and CD8+ lymphocytes in cancer cell nests. Distribution of adequate amounts of T lymphocytes subsets may be necessary in order for good tumor response to biotherapy with rIL-2; other clinical and histopathological variables predicting the effect for cancer chemotherapy remain to be identified.
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