Abstract
Hiccup is a spasmodic, involuntary contraction of the inspiratory muscles, associated with delayed, abrupt glottic closure, causing a peculiar sound. There are numerous causes of hiccup, including diseases of the gastrointestinal tract. Hiccup is reported to represent an atypical manifestation of the gastroesophageal reflux disease (GERD). We report two cases with hiccup due to GERD. Endoscopic examinations showed esophagitis, Los Angeles class grade A and B, in two cases whose hiccups were improved by proton pump inhibitors (PPI). Hiccup is atypical symptom of GERD. If hiccup is due to GERD, then it may be improved with ppi therapy.
Highlights
Hiccup, or singultus, is a spasmodic, involuntary contraction of the inspiratory muscles, associated with delayed, abrupt glottic closure, causing a peculiar sound (1)
If hiccup is due to gastroesophageal reflux disease (GERD), it may be improved with ppi therapy
Toxins, drugs and metabolic abnormalities may lead to hiccup (2)
Summary
Singultus, is a spasmodic, involuntary contraction of the inspiratory muscles, associated with delayed, abrupt glottic closure, causing a peculiar sound (1). If hiccup is due to GERD, it may be improved with ppi therapy. Toxins, drugs and metabolic abnormalities may lead to hiccup (2). Hiccup is reported to represent an atypical manifestation of the gastroesophageal reflux disease (GERD) (3). Abdominal ultrasonography and computarized tomography (CT) scan of the brain were normal.
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