Two cases of esophageal carcinoma following corrosive esophagitis successfully treated with chemoradiation therapy

Abstract

AbstractBackground: Ingestion of corrosive substances can be associated with severe damage to the esophagus, resulting in strictures. It is also known to be associated with an increased incidence of esophageal carcinoma. In many such cases surgery to cure the cancer is compromised by earlier surgery for corrosive damage or due to fibrosis.Methods: We reviewed a database of 1246 patients collected between 1988 and 2006 with esophageal cancer. Squamous cell carcinomas arising in two patients with previous corrosive esophagitis were identified.Results: Both patients were treated with definitive cisplatin‐based chemoradiation therapy. In both cases a complete response occurred and after a minimum follow up of 4 years, both cases remain in remission.Conclusions: We conclude that definitive chemoradiation therapy can be successful in the management of squamous cell carcinoma arising patients with corrosive esophagitis.