Abstract
A 21-year-old female and a 23-year-old female with advanced atrioventricular block in the course of hyperthyroidism were reported.In the latter case, the febrile illness was associated immediately preceding the onset of the heart-block. The sore throat, polyarthralgia, pericarditis, leukocytosis, high erythrocyte sedimentation rate and ASO titre are compatible with a diagnosis of acute rheumatic fever, but a typical cardiac murmur was absent.In the former case, an unexplained inflammation was suspected by elevated sedimentation rate, positive C-reactive protein, increased γ-globulin and subsequent course, although she was apyrexial.In both our cases, therefore, the development of advanced A-V block might be due to the summation of delayed conduction induced by hyperthyroidism and infection or inflammation, as most previous reports suggested.
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