Abstract
We describe the case of a 74-year-old female patient previously treated with radiation therapy for a meningioma of the skull base and with surgery for a right tympanic paraganglioma. After the morphological progression of the meningioma demonstrated by magnetic resonance imaging (MRI), the patient underwent somatostatin receptor positron emission tomography/computed tomography (SR-PET/CT) with Gallium-68 DOTATATE for restaging. This examination showed increased somatostatin receptor expression by the meningioma and confirmed its extension as already assessed by MRI (endocranial extension, skull base involvement and invasion of the right orbit). Furthermore, SR-PET/CT detected two small right jugulotympanic pararagangliomas with high somatostatin receptor expression. Lastly, SR-PET/CT demonstrated that this patient would be an ideal candidate for peptide receptor radionuclide therapy (PRRT) that can be used for the treatment of progressive/treatment-refractory meningiomas and relapsed paragangliomas with high somatostatin receptors expression, both conditions coexisting in this case.
Highlights
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PET demoansssetsrsaetdedbythMaRtI.thInitsermesetinnginlyg, iSoRm-PaETparlessoernevteeadlead htwigohareexasporfeisnsciroenaseodf usoptmakaetoofsrtaadtiionlarbeecleedptsoomrsaatonsdtatcinonanfairlomgueeds the extension of thecolrersesioponndailnregatodtywaosssmeaslslerdighbtyjugMulRoIty. mInptaenriec sptairnagglayn,glSioRm-PasElTocaatlesdoinrethveeraiglehdt jutwguolarafroeraasmeonf ainndcrtheeasriegdhtumpidtadklee of radiolabeled soemara, troessptaecttiinvealyna(rleodgaureroswcsoirnreCs,Dpo1,nDd2i,En1g,Et2o). tTwheoSsUmVamlalx roifgthhtesjeupgaurlaogtaynmglpioamnaiscwpaasr2a1g5a. nTghleisoempaarsagloancgaltieodmaisn the right jugular forsahmoweendainncdretahseedriegxhprtemssiiodndolfeseoamra, troesstapteinctrievceeplyto(rrseadccaorrdroinwg stoinSRC-P,DET1,fiDnd2i,nEg1s,Ean2d).oTnhlyeoSnUe Vofmthaxeomf wthaessdeepscarirbaegdangliomas was 215
In the described unusual case with concurrent presence of progressive meningioma and relapsed paragangliomas, SR-PET allowed correct evaluation of these tumors based on their increased somatostatin receptors expression
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Gnostics 2021, 11, x FOR PEER REVIEW PET demoansssetsrsaetdedbythMaRtI.thInitsermesetinnginlyg, iSoRm-PaETparlessoernevteeadlead htwigohareexasporfeisnsciroenaseodf usoptmakaetoofsrtaadtiionlarbeecleedptsoomrsaatonsdtatcinonanfairlomgueeds the extension of thecolrersesioponndailnregatodtywaosssmeaslslerdighbtyjugMulRoIty. mInptaenriec sptairnagglayn,glSioRm-PasElTocaatlesdoinrethveeraiglehdt jutwguolarafroeraasmeonf ainndcrtheeasriegdhtumpidtadklee of radiolabeled soemara, troessptaecttiinvealyna(rleodgaureroswcsoirnreCs,Dpo1,nDd2i,En1g,Et2o).
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