Abstract
Two new antimycin A analogues, antimycin B1 and B2 (1–2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
Highlights
Marine actinomycetes are chemically rich sources of structurally diverse secondary metabolites.The vast majority of these secondary metabolites is mainly derived from members of the genusMar
289 secondary metabolites from the marine-derived genus of Streptomyces are reported in the Marinlit database, covering a wide variety of chemical structures, including peptides, macrolides, lactones, indoles, terpenes, and quinones
These compounds show an extensive range of activities, such as cytotoxic, antibacterial, antifungal and antimalarial [3]
Summary
Marine actinomycetes are chemically rich sources of structurally diverse secondary metabolites. The vast majority of these secondary metabolites is mainly derived from members of the genus. 289 secondary metabolites from the marine-derived genus of Streptomyces are reported in the Marinlit database, covering a wide variety of chemical structures, including peptides, macrolides, lactones, indoles, terpenes, and quinones. These compounds show an extensive range of activities, such as cytotoxic, antibacterial, antifungal and antimalarial [3]. In our endeavor to search for novel antibacterial secondary metabolites from marine Streptomyces using bioassay and LC-UV/Vis-MS guided methods, we isolated two new antimycin A analogues. 20 antimycin A compounds have been reported [10]. We report on the discovery of the first naturally occurring ring-opened antimycin A analogues which were named as antimycin B1 and B2 (Figure 1) as well as their antibacterial activity
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