Abstract
Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
Highlights
The genus Dracaena (Agavaceae) includes more than 50 species found in tropical and subtropical regions of the eastern hemisphere
The MeOH extracts of the whole plant of D. angustifolia Roxb. was extracted successively with
Two new steroidal saponins 1–2, one known steroidal saponin 3, and seven known benzenoids 4–10 were isolated from the MeOH extract of D. angustifolia Roxb
Summary
The genus Dracaena (Agavaceae) includes more than 50 species found in tropical and subtropical regions of the eastern hemisphere. Previous phytochemical investigations on the genus Dracaena have reported the presence of a variety of components, including steroidal saponins [3,4,5,6,7], flavonoids [5,8,9,10], and phenolic compounds [8,11]. The pharmacological investigation indicated that the C27 steroidal saponins present on the genus Dracaena showed broad biological activities, such as anti-inflammatory, antifungal, antimicrobial, antiviral, analgesic, antioxidative, cytotoxic, and hypoglycemic properties [3,4,5,11]. The production of vast amounts of superoxide anion and elastase by activated neutrophils can cause tissue damage and contribute to the development of a wide spectrum of airway inflammatory diseases [15,16]. The anti-inflammatory activity of new compounds was evaluated as inhibitory activities against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion production and elastase release in human neutrophils
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