TWISTER PLOTS FOR TIME-TO-EVENT STUDIES.

Abstract

Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. The twister plot is a −90-degree rotation of a typical contrast measure plot (e.g., Figure 3 in Cole et al. (3)), whereby the contrast measure is instead on the abscissa (x-axis) and time on the ordinate (y-axis). Pointwise confidence intervals are similarly added as a shaded region that typically widens as follow-up duration increases, giving twister plots their characteristic shape that resembles their namesake. To ease application, we provide SAS, R, and Python code on GitHub (4). In Figure 1A...