Abstract
With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined. In this study, we found that Twist1, participating in a variety of cell biological process, was associated with the malignancy of NPC and could induce NPC radioresistance in vitro and in vivo. Mechanically, Twist1 could promote the accumulation of DNA damage repair and inhibit the apoptosis of NPC cells. Therefore, our study not only elucidates the significant role of Twist1 in radioresistance of NPC, but also highlights Twist1 as a potential therapeutic target for NPC.
Highlights
Nasopharyngeal carcinoma (NPC), arising from the mucosal epithelium of the nasopharynx, is a locally malignant cancer with high metastatic potential [1]
We found that Twist1, participating in a variety of cell biological process, was associated with the malignancy of nasopharyngeal carcinoma (NPC) and could induce NPC radioresistance in vitro and in vivo
We examined the expressions of Twist1 in NPC samples via immunohistochemistry (IHC) approach and observed that the cancerous tissues displayed remarkably higher levels of Twist1 relative to the adjacent normal tissues (Figure 1A)
Summary
Nasopharyngeal carcinoma (NPC), arising from the mucosal epithelium of the nasopharynx, is a locally malignant cancer with high metastatic potential [1]. Twist has been found to be a vital oncogene that promotes the development and progression of malignant tumor by enhancing tumorrelated functions such as epithelial-to-mesenchymal transition (EMT), angiogenesis, degeneration of ECM, and anti-apoptosis [5, 6]. In NPC, Twist has been suggested to contribute to metastasis, malignant progression [7] and drug resistance (Taxol) of tumor [8]. Since Twist is an EMT regulator and plays a key role in the development of NPC, Twist may be a potential factor to be related to radioresistance. It is still unclear whether Twist could induce radioresistance of NPC
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