Abstract
To the Editor.— Recent communications inThe Journal, an article by Wong and Schultz (238:1741, 1977) and a letter by Sostre (239:1035, 1978), have summarized data suggesting that the radioactive iodine uptake (RAIU) in normal persons declined during the 20 years from 1957 to 1977. Hooper and Caplan (238:411, 1977) indicate that increased dietary iodine content may be the cause of decreasing RAIU values in hyperthyroid patients as well as in normal persons. They found a notable change in hyperthyroid patients with toxic nodular goiter. However, they did not find an appreciable change in the RAIU values for patients with Graves' disease between 1970 and 1976. Between 1965 and 1977 we treated 466 patients for hyperthyroidism using radioactive iodine. During these years we found that the 24-hour RAIU values for hyperthyroid patients remained essentially unchanged, between 45% and 55% (Figure), within the usually accepted hyperthyroid range. Of these 466 patients,
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