Twelve-month prospective study of polymethylmethacrylate/collagen dermal filler for volume loss of the dorsal of hands.

Abstract

Dermal fillers have been used safely and effectively to revolumize aging hands. We assess the effectiveness of polymethylmethacrylate (PMMA) to treat the volume loss of photoaged dorsal hands for up to 12months. In a 12-month prospective study, 15 subjects were treated with PMMA filler in the bilateral dorsal hands. PMMA was injected 4weeks after an initial screening visit, and touch-up treatments were provided if needed 4weeks later. Effectiveness was assessed by the provider using the validated Merz Hand Grading Scale (MHGS) and the Global Aesthetic Improvement Scale (GAIS). Subjects completed the Subject GAIS and the Subject Satisfaction Survey. All subjects had at least 1 point of improvement on the MHGS starting from 1month to 12months after treatment. 75% of subjects had a 2-point improvement at 12months. Investigators reported that 92% of subjects had some degree of improvement at 12months, while 75% of subjects self-reported some degree of improvement. Approximately 75% of the subjects reported that they were satisfied with the treatment. Adverse events were minor and limited to swelling. PMMA is a safe and effective treatment for volumizing the dorsal hands with improvement that is sustained for up to 12months.