TVL1-IMPT: Optimization of Peak-to-Valley Dose Ratio Via Joint Total-Variation and L1 Dose Regularization for Spatially Fractionated Pencil-Beam-Scanning Proton Therapy

Abstract

Proton minibeam radiation therapy (pMBRT) is a novel proton modality of spatially fractionated RT. pMBRT can reduce the radiation damage to normal tissues via biological dose sparing of high peak-to-valley dose ratio (PVDR). This work will develop a new spatially fractionated IMPT treatment planning method for pMBRT that jointly optimizes the plan quality and maximizes the PVDR. The new optimization method simultaneously maximizes the normal-tissue PVDR and optimizes the dose distribution at tumor targets and organs at risk. The PVDR maximization is through the joint total variation (TV) and L1 regularization with respect to the normal-tissue dose. That is, the beam-eye view projects dose slices of several depths for each beam angle; the TV of dose is maximized, corresponding to the PVDR maximization; and the L1 of dose is minimized, corresponding to the minimization of the organs-at-risk dose and maximization of survival fraction (SF). The new IMPT method with TV and L1 regularization was validated in comparison with the conventional IMPT method for pMBRT in several clinical cases. The results show that TVL1 provided larger PVDR and SF than the conventional IMPT method for biological sparing of normal tissues, with preserved plan quality in terms of physical dose distribution. A new spatially fractionated IMPT treatment planning method was developed for pMBRT that can optimize and improve normal-tissue PVDR and SF by incorporating TV and L1 dose regularization with properly chosen regularization parameters into IMPT.