Abstract
1.1. The turnover of sulfated glycosaminoglycans was studied in the rat aortic wall. Carrier-free radioactive sulfate was administered by intraperitoneal injection to young and old rats. The specific activity and half-time of sulfated glycosaminoglycans were determined.2.2. In dermatan sulfate, the specific activity and half-time were respectively higher and shorter than in the other glycosaminoglycans.3.3. Incorporation of radioactive sulfate in every glycosaminoglycan was decreased in old rats compared to young rats. The half-time was increased in ol d rats.4.4. These results suggest a diminution of glycosaminoglycan metabolism in the aortic wall with aging.
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