Abstract
Abstract We report on a strategy for the “turn-on” detection of target biochemical (metabolic) reactions using a triple resonance NMR technique with an isotope-labeled probe. Our NMR study clearly reveals that otherwise NMR-nonactive-13C/2H-labeled glucose actually turns “on” its 1H NMR signal by conversion to an important biomarker lactate as the end product of anaerobic glycolysis in cells and in injected mice with high selectivity.
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