Abstract
The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic loci are uncorrelated and influenced by the local chromatin environment.
Highlights
The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive
Since the discovery of this phenomenon, scientists have wondered whether gene expression levels are controlled by the size or the frequency of these random bursts (Singh et al, 2010; Suter et al, 2011; Dar et al, 2012; Senecal et al, 2014). mRNAs are usually short lived and begin to decay immediately after their synthesis
In addition to the state of local chromatin, gene expression levels depend on the promoter architecture, the concentration of the transcription factors (TFs) present in the cell and their ability to recruit the RNA polymerase complex to the gene locus
Summary
The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. Since the discovery of this phenomenon, scientists have wondered whether gene expression levels are controlled by the size or the frequency of these random bursts (Singh et al, 2010; Suter et al, 2011; Dar et al, 2012; Senecal et al, 2014).
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