Abstract
This letter reports on a method for producing on demand calibrated bubbles in a non-chemically controlled solution using localized micro-electrolysis and ultrasound. Implementing a feedback loop in the process leads to a point source of stable mono-dispersed microbubbles. This approach overcomes the inertial constraints encountered in microfluidics with the possibility to produce from a single to an array of calibrated bubbles. Moreover, this method avoids the use of additional surfactant that may modify the composition of the host fluid. It impacts across a broad range of scientific domains from bioengineering, sensing to environment.
Highlights
The consideration of nano and micro bubbles of controlled size shows a growing interest over a wide range of topics in physics and in chemistry
Impedance contrast is clinically exploited in ultrasonography through the use of contrast agents.[10]
Lee et al.[16] investigated several methods to produce microbubbles. They can be classified into stochastic approaches, forced extrusion methods, template layer-by-layer deposition,[17] and microfluidics methods
Summary
The consideration of nano and micro bubbles of controlled size shows a growing interest over a wide range of topics in physics and in chemistry. This principle is exploited in the process by considering a high frequency (1 MHz) pressure field that induces in phase bubbles oscillations.
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