Abstract
This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and core parts of the nanofibers, respectively. Scanning and transmission electron microscopy demonstrated that the nanofibers had linear morphologies and core-shell structures. The quercetin was found to be present in the nanofibers in the amorphous physical status, on the basis of X-ray diffraction results. In vitro release profiles showed that the PVP shell very rapidly freed its drug cargo into the solution, while the EC core provided the succedent sustained release. Variation of the drug loading permitted the release profiles to be tuned.
Highlights
Since the first report of drug-loaded nanofibers fabricated using electrospinning [1], these materials have been widely explored in the biomedical field [2,3,4,5]
This study offers a simple approach for the systematic design and fabrication of biomaterials to provide complicated and programmable drug release profiles
A PVCcoated concentric spinneret was developed to conduct coaxial electrospinning, and quercetin-loaded core-shell nanofibers with tunable biphasic release profiles were fabricated. This could be achieved despite the fact that the shell fluid alone was found not to be electrospinnable
Summary
Since the first report of drug-loaded nanofibers fabricated using electrospinning [1], these materials have been widely explored in the biomedical field [2,3,4,5]. A wide variety of technologies have been exploited to generate drug delivery systems with biphasic release profiles Electrospinning can achieve this objective through strategies such as preparing multi-layered nanofiber mats or producing nanofibers containing nanoparticles [21,24]. Core-shell nanofibers generated using coaxial electrospinning have been reported to offer biphasic release, with a fast-dissolving shell delivering immediate release followed by sustained release from the core [22]. Both the core and shell fluids used for coaxial spinning have been electrospinnable in such studies [23]
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