Abstract
Tumour budding (TB) in cancer is aphenomenon oftumour cells forming clusters, and it is associated with an epithelial-mesenchymal transition into theextracellular matrix ofthetumour. It has been shown that thepresence ofTB in colorectal cancer (CRC) is associated with worse overall survival, higher possibility for vessel invasion, lymph node involvement, and distant metastases appearance. In this retrospective study TB presence in operated patients for CRC is analysed. In thedata from 81 patients, 26 presented with TB. Analysis revealed high statistical significance oftheeffect ofTB presence on thenumber ofmetastatic lymph nodes, and thelymphovascular and perineural invasion. Astatistically meaningful correlation was found between thepresence ofTB and CRC survival ( p = 0.016). Patients with right-sided colon cancer presented with worse overall survival ( p = 0.011). Thepatients who presented lymph node metastases and TB presence had worse overall survival ( p = 0.026 and p = 0.021, respectively). Tumour budding, tumour location, and age over 64 years are found to be theindependent prognostic factors in CRC patients. Tumour budding is an important prognostic factor in CRC patients that will contribute to treatment. Pathological examination must consider TB in detail.
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Schedule a callMore From: Polish journal of pathology : official journal of the Polish Society of Pathologists
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