Abstract
Immune response is known to develop against malignant tumours. Malignant tumours express newer antigen on their cell surface membrane which elicit immunological reaction in and around tumoural tissue. In early part of immune reaction neutrophil, eosinophil migrates followed by monocyte-macrophage cell. Tumor associated tissue eosinophilia (TATE) is believed to play a significant role in the biological behavior of the carcinoma. Eosinophil infiltrate in association with the head and neck squamous cell carcinoma (SCC) have been reviewed from time-to-time. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of this study was to investigate and evaluate the possible role of the tumour associated tissue eosinophilia (TATE) as a predictive indicator for the grading and establishing prognosis of the upper aerodigestive tract squamous cell carcinoma (SCC).
Highlights
Inflammatory infiltration with eosinophil as a result of immune reaction against tumour antigen in or around the tumoural tissue varies among the cases with squamous cell carcinoma (SCC) of upper aero digestive tract
In our study 58 cases of squamous cell carcinoma involving oral cavity, pharynx and larynx except nose and nasopharynx were biopsied in department of ENT and Head, Neck Surgery, MLB Medical College, Jhansi (INDIA) for the evaluation of tumour associated tissue eosinophilia
Borders are classified into the following types: 1) Large pushing borders and broad cords 2) Borders invading as single cell or small cords Squamous cell carcinoma is classified into 3 grades based on the degree of keratinisation and nuclear atypia namely: 1) Well differentiated SCC 2) Moderately differentiated SCC 3) Poorly differentiated SCC In our study, the histopathological findings like borders, grading and cytological indicator tumour associated tissue eosinophilia were analysed as prognostic indicator for the squamous cell carcinoma of upper aero digestive tract including oral cavity, pharynx and larynx except nose and nasopharynx
Summary
Inflammatory infiltration with eosinophil as a result of immune reaction against tumour antigen in or around the tumoural tissue varies among the cases with squamous cell carcinoma (SCC) of upper aero digestive tract. The aim of this study was to investigate and evaluate the possible role of the tumour associated tissue eosinophilia (TATE) as a predictive indicator for the grading and establishing prognosis of the upper aerodigestive tract. (2016) Tumour Associated Tissue Eosinophilia as a Prognostic Indicator in Squamous Cell Carcinoma of Upper Aerodigestive Tract. In our study 58 cases of squamous cell carcinoma involving oral cavity, pharynx and larynx except nose and nasopharynx were biopsied in department of ENT and Head, Neck Surgery, MLB Medical College, Jhansi (INDIA) for the evaluation of tumour associated tissue eosinophilia. The tumour with pushing border and broad cords of cells have better prognosis whereas tumours which invade as single cells or small irregular cords (non-pushing) have relatively poor prognosis [3]
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