Tumors induced in hamsters by a respiratory-associated canine adenovirus (A26-61).

Abstract

Sarcomas were induced in the subcutis of hamsters by a respiratory-associated (RA) canine adenovirus, A26/61. The tumors were transplantable in vivo and retained their oncogenic properties after in vitro cultivation. Hamsters bearing RA-induced tumors developed complement-fixing antibodies against T antigens prepared in cell culture. The sera reacted to a lesser degree with T antigens induced by infectious canine hepatitis (ICH) virus, but not with those induced by an unrelated simian adenovirus.