Abstract
Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells
Highlights
Endocrine-disrupting chemicals (EDCs) are natural or industrial compounds found in food and the environment that are capable of mimicking some of the effects of endogenous estrogens or interfering with estrogen signaling pathways by interacting with two estrogen receptors (ERs): ERα and ERβ (Pelekanou and Leclercq, 2011; Kerdivel et al, 2013)
This study investigated the antiproliferative activity of licorice (Glycyrrhiza glabra) root extract (LRE) in TCDD-stimulated MCF-7 human breast cancer cells
LRE mitigated the tumorigenic effects of TCDD in MCF-7 cells by suppressing aryl hydrocarbon receptor (AhR) expression and cell cycle arrest
Summary
Endocrine-disrupting chemicals (EDCs) are natural or industrial compounds found in food and the environment that are capable of mimicking some of the effects of endogenous estrogens or interfering with estrogen signaling pathways by interacting with two estrogen receptors (ERs): ERα and ERβ (Pelekanou and Leclercq, 2011; Kerdivel et al, 2013). EDCs that target ER signaling can induce ER activity directly or indirectly through three signal pathways: directly through interactions with ERs, indirectly through transcription factors such as aryl hydrocarbon receptor (AhR), or through modulation of metabolic enzymes that are critical for normal estrogen synthesis and metabolism (Bidgoli et al, 2011; Shanle and Xu, 2011). TCDD, as a kind of EDC, has multiple endocrine activities and has been known to increase the incidence of breast cancer in regions contaminated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) (Warner et al, 2002). After dimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT), the complex binds to the
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