Abstract
BackgroundDJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance of DJ-1 in supraglottic squamous cell carcinoma (SSCC) is unclear. We aimed to evaluate the DJ-1 the relationship between DJ-1 and clinicopathological data including patient survival.MethodsThe expression of DJ-1 and PTEN in SSCCs (52) and adjacent non-cancerous tissues (42) was assessed by immunohistochemistry (IHC), and the relationship between DJ-1 and clinicopathological data was analyzed.ResultsDJ-1 was detected mainly in SSCCs (88.5%) and less frequently in adjacent non-cancerous tissues (21.0%). PTEN expression was detected in 46.2% of SSCCs and in 90.5% of adjacent non-cancerous tissues. DJ-1 expression was linked to nodal status (P = 0.009), a highly significant association of DJ-1 expression with shortened patient overall survival (5-year survival rate 88.0% versus 53.9%; P = 0.007; log rank test) was demonstrated.ConclusionsOur data suggested that DJ-1 over-expression was linked to nodal status, and might be an independent prognostic marker for patients with SSCC.
Highlights
DJ-1 can induce the tumor cell proliferation and invasion via down-regulating Phosphatase and tensin homologue (PTEN) in many malignant tumors, and correlated to prognostic significance
To better study the cellular location and the relationship between DJ-1 and PTEN in squamous cell carcinoma (SSCC), fluorescent immunohistochemistry was performed, and the results showed that strong expression of DJ-1 is found in cytoplasm of SSCC tumor cells, while poor staining of PTEN was observed in cytoplasm of SSCC tumor cells, and that strong expression of PTEN is found in cytoplasm of adjacent non-cancerous cells, while poor staining of DJ-1 was observed in cytoplasm of adjacent non-cancerous cells (Figure 1B)
DJ-1 expression was detected in 88.5% of SSCCs and in 21.0% of adjacent non-cancerous tissues examined, whereas PTEN expression was detected in 46.2% of SSCCs and in 90.5% of adjacent non-cancerous tissues
Summary
DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. The tumorigenesis role and clinical significance of DJ-1 in supraglottic squamous cell carcinoma (SSCC) is unclear. Supraglottic squamous cell carcinoma (SSCC), one advanced type of LSCC, is often accompanied by lymph node metastasis or even systemic metastasis, and usually results in substantial annual morbidity and mortality. The evaluation of a SSCC patient’s prognosis and predictive markers is primarily based on the clinical tumor-. Recent studies indicated that DJ-1 is closely related to the proliferation, metastasis, occurrence, and prognosis of the malignant tumors [2,5,6,7,8,9,10,11,12,13]. In our recent study of glottic squamous cell carcinoma [2], DJ-1 was shown as an independent molecular marker for poor prognosis, and was correlated with pT status and tumor grading. The relationship between DJ-1 and lymph node metastasis of LSCC have not been revealed both in our and others’ studies
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