Tumorigenesis in mice with an SV40 T antigen transgene driven by the immunoglobulin gamma 1 heavy chain germline promoter.

Abstract

The immunoglobulin heavy chain switch is a genetic recombination whereby a V(D)J region is rearranged from association with the Cµ gene to association with a downstream Cγ, Cε, or Cα gene [1,2). The recombination event occurs in switch (S) regions found upstream of each CH gene except Cδ. Switch recombination is preceded by a change in the “accessibility” of the switch region DNA, as indicated by the induction of transcription of the CH locus prior to switch recombination [1–4]. Both induction of germline transcripts and switch recombination of any CH locus are specifically regulated by cytokines.KeywordsHarderian GlandGermline TranscriptAntigen Transgenic MouseHeavy Chain Class SwitchingChain Class SwitchingThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.