Abstract
Tumoral Necrosis Factor (TNF) mRNA gene expression in relation to Vascular Endothelial Growth Factor (VEGF) and chemokines mRNA gene expression in tumoral microenvironment of endometrial cancer versus normal endometrium: Preliminary results
Highlights
Tumor microenvironment inflammatory cells play a major role in cancer progression
In the comparison between normal endometrium (NE) versus endometrial cancer (EC), we found down-regulation of Tumour Necrosis Factor (TNF) mRNA in 73%, Vascular Endothelial Growth Factor (VEGF) mRNA up-regulation in 54%, CXCL12 down-regulation in 91% of samples, down-regulation of CXCL11 of 54% and CXCL8 up-regulation in 64% of samples
Directly statistically significant correlation found among downregulation of TNF, CXCL12 and CXCL8, seem to suggest a reduced ability of the host immune response against the cancer invasiveness and growth of the tumoral microenvironment
Summary
Tumor microenvironment inflammatory cells play a major role in cancer progression. Tumour Necrosis Factor (TNF) induces apoptosis in a variety of cancer cells playing a role in cancer growth and metastasis. Some chemokines and growth factors are related to TNF in many tumours In this preliminary study we compared the TNF, VEGF, CXCL8, CXCL12, CXCL11 mRNA gene expression in normal endometrium (NE) versus endometrial cancer (EC) microenvironment. Tumour microenvironment inflammatory cells play a major role in cancer progression by the production of proteins mediators: chemokines, cytokines and growth factors. Among these mediators, Tumour Necrosis Factor (TNF) is a pro-inflammatory cytokine produced by activated macrophages and other cells of the tumour microenvironment, inducing apoptosis in a variety of cancer cell types playing a role in cancer growth and metastasis [1,2,3]. In breast cancer cells the increased CXCL8 expression level reflects increased invasiveness into
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