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Abstract
A substantial amount of data suggests that both RNA and DNA tumor viruses are associated with human cancer. Correction of malignant transformation at the genotypic level may be possible in the future but will require significant advances in our understanding of genomic material. The use of simple defined models such as tumor viruses seems like a reasonable place to start. The use of antipromotors (e.g. retinoids) and inhibitors of promotors will prove as important to the successful treatment of cancer in the next decade as chemotherapy has been in the last two decades.
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