Abstract
Background/ObjectivesTo prospectively examine the relation between tumor vascularity and glucose metabolism in adenocarcinoma (AC) and squamous cell carcinoma(SCC) of the lung by using positron emission tomography/computed tomography (PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).Materials and MethodsForty-one consecutive patients with histologically confirmed untreated NSCLC underwent routine diagnostic work-up, including DCE-MRI and PET/CT. PET/CT images were used to derive glucose metabolism (SUVmax and SUVmean), and DCE-MRI images were used to derive tumor vascularity (Ktrans, Kep, Ve and iAUC). Any differences in the DCE-MRI and PET/CT estimations between the NSCLC subtypes were determined by the Wilcoxon rank sum test. Spearman’s rank correlation coefficients were calculated between the DCE-MRI parameter values and the SUV.ResultsSUVmean and SUVmax in AC were significantly lower than in SCC, but Ktrans and Ve in AC were significantly higher than in SCC. Significant correlations between SUV and DCE-MRI parameters were observed for SUVmax and Ve (ρ = −0.357, P = 0.022), SUVmean and Ktrans (ρ = −0.341, P = 0.029), and SUVmean and iAUC (ρ = −0.374, P = 0.016 ) in total; for SUVmax and iAUC (ρ = −0.420, P = 0.037), SUVmean and Ktrans (ρ = −0.411, P = 0.041), SUVmean and Kep (ρ = −0.045, P = 0.026), and SUVmean and iAUC (ρ = −0.512, P = 0.009) in AC; However, for neither in SCC.ConclusionAC and SCC showed different patterns in both tumor vascularity and glucose metabolism. Tumor vascularity and glucose metabolism negatively correlated in AC, but not in SCC. These differences may underlie the heterogeneity in clinical aspect of NSCLC subtypes and have implications for their imaging profiling and monitor the treatment response.
Highlights
For therapeutic purposes, non-small cell lung cancer (NSCLC) has traditionally been regarded as a single disease
Significant correlations between SUV and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) parameters were observed for SUVmax and Ve (r = 20.357, P = 0.022), SUVmean and Ktrans (r = 20.341, P = 0.029), and SUVmean and iAUC (r = 20.374, P = 0.016 ) in total; for SUVmax and iAUC (r = 20.420, P = 0.037), SUVmean and Ktrans (r = 20.411, P = 0.041), SUVmean and Kep (r = 20.045, P = 0.026), and SUVmean and iAUC (r = 20.512, P = 0.009) in AC; for neither in squamous cell carcinoma (SCC)
Tumor vascularity and glucose metabolism negatively correlated in AC, but not in SCC
Summary
Non-small cell lung cancer (NSCLC) has traditionally been regarded as a single disease. Fundamental discrepancies in tumor biology of NSCLC subtypes may be a primary factor determining the differential clinical manifestation. Both tumor vascularity and glucose metabolism are important aspects of the tumor biology. He recognized that glucose can be metabolized either by combination with oxygen, i.e. respiration, or by glycolysis to produce lactate He observed that a change from oxidative phosphorylation to the less energy efficient glycolysis, even in the presence of an adequate supply of oxygen, is a fundamental property of the metabolism of cancer cells and that the rate of glycolysis correlated with tumor growth. Warburg’s findings underpin the principles of tumor imaging with fluorodeoxyglucose positron emission tomography (FDG-PET) [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
