Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

Yangyang Liu,Zhiyu Qian,Jianhua Yin,Xiao Wang

doi:10.1142/s179354581550008x

Abstract

Magnetic nanoparticle plays an important role in biomedical engineering, especially in tumor therapy. In this paper, a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-frequency alternating magnetic field (LFAMF) to kill tumor cells. The LFAMF system which was used to drive magnetic nanoparticles (MNPs) was setup with the magnetic field frequency and power range at ∼ 10–100 Hz and ∼ 10–200 mT, respectively. During the experiment, the LFAMF was adjusted at different frequencies and power levels. The experimental results show that the liver tumor cells (HepG2) mixed with MNPs (10 μg/mL) became partial fragments when exposed in the LFAMF with different frequencies (∼ 10–100 Hz) and power (∼ 10–200 mT), and the higher the frequency or the power, the more the tumor cells were killed at the same magnetic nanoparticle concentration. Conclusion: Tumor cells were effectively damaged by MNPs under LFAMF, which suggests that they had great potential to be applied in tumor therapy.

Highlights

Radiotherapy and chemotherapy are mostly used for cancer treatment
magnetic nanoparticles (MNPs)–Fe3O4 and HepG2 cells were observed after 8 h, and some particles were found in large bubble structure, while they were not found in the nucleus
It was demonstrated that tumor cells growth was modulated by the cooperation of internalized MNP– Fe3O4 and the external exposure of LFAMF

Summary

Introduction

Radiotherapy and chemotherapy are mostly used for cancer treatment. Both methods are not optimal as they damage normal tissue and produce a series of adverse reactions while damaging tumor cells. Much e®ort has been devoted to the research of more e±cient cancer therapies. Nanotechnology approaches are currently the most promising.[1,2,3,4,5] The use of nanoparticles has attracted more attention due to their inherent ultra- ̄ne size, optical characteristics, biocompatibility, and magnetic properties.[6,7] Amongst nanoparticles, magnetic nanoparticles (MNPs) is the choice of many researchers. MNPs share special properties such as strong magnetic responsiveness, high saturationeld, and no magnetic interaction after the external magneticeld is removed.[8,9] The functional properties of the MNPs can be applied for specic biological functions, such as drug delivery, hyperthermia, magnetic targeting, magnetic

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Discussion

Conclusion